single-cell high-throughput microfluidic tapestri platform (Mission Bio)
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Single Cell High Throughput Microfluidic Tapestri Platform, supplied by Mission Bio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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Article Title: Single-cell analysis reveals selection of TP53 -mutated clones after MDM2 inhibition
Journal: Blood Advances
doi: 10.1182/bloodadvances.2021005867
Figure Legend Snippet: Clonal architecture of TP53 -mutated MPN patients. Phylogenetic trees show the order of mutation acquisition during MPN history with maximum likelihood in 8 patients. The mutational history was manually reconstructed from the single-cell data. In the case of MPN3, it was not possible to infer the order of mutation acquisition in JAK2 and U2AF1 because of the absence of cells with wild-type version of these genes. Each circle represents a clone identified in single-cell analysis using Tapestri platform and Tapestry Insights software (Mission Bio). The size of each circle denotes the relative clone size. The nomenclature of each mutation is indicated only when 2 or more mutations were present in the same gene.
Techniques Used: Mutagenesis, Single-cell Analysis, Software
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